Pembrolizumab and Chemotherapy in Cervical Cancer: A New Standard of Care?
نویسندگان
چکیده
Cervical cancer (CC) still has a high incidence despite screening programmes and access to human papillomavirus (HPV) vaccination, with poor prognosis in the advanced setting. Most cases of cervical carcinoma are related HPV infection. The pathogen-induced nature disease, involvement genes regulating immune response grade infiltration provide rationale evaluate anti-programmed death-(ligand)1 (PD-[L]1) checkpoint inhibitors CC. This article reviews promising outcomes KEYNOTE-826 phase III trial, which evaluates addition pembrolizumab chemotherapy patients PD-L1-positive disease recurrent, persistent or metastatic cervix, leading an improvement progression-free survival overall survival. We also aim address some outstanding questions discuss next steps immunotherapy for
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ژورنال
عنوان ژورنال: Touch reviews in oncology & haematology
سال: 2022
ISSN: ['2752-5481']
DOI: https://doi.org/10.17925/ohr.2022.18.1.2